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Physicians Drug Manual
Dosages, Side Effects, Drug Interactions, and Newly Approved Drugs
Updated and Revised
Individual Drug Preparations
Abacavir (Ziagen) Antiretroviral Tab: 300 mg 300 mg bid in combination with other antiretroviral agents. Fatal hyper-Oral soln: 20 mg/mL sensitivity reactions, lactic acidosis.
Abciximab (ReoPro) Antiplatelet agent Inj: 5 mg/10 mL 0.25mg/kg IVP, then 0.125 mcg/kg/min (max 10 mcg/min) for 12 hrs. Thrombocytopenia; possible anaphylaxis on re-exposure in 1 year.
Acarbose (Precose) Hypoglycemic Tab: 50, 100 mg Initially 25 mg (½ tab) tid, then 50-100 mg tid with first bite of each meal. Delays carbohydrate absorption, modestly reduces glucose. Flatulence, bloating, diarrhea common.
Acebutolol (Sectral) Antiarrhythmic Cap: 200, 400 mg 200 mg bid, increase up to 600 mg bid; cardioselective, intrinsic beta-Antihypertensive activity; less bradycardia at restAcetaminophen Analgesic Tab, cap: 160, 325, 325-650 mg (1-2 tab) tid-qid; overdose causes hepatotoxicity, renal (Tylenol) Antipyretic 500, 650 mg failure
Elixir: 325 mg/5 mL, 160 mg/5 mL, 120 mg/5 mL
Suppository: 120, 125, 325, 650 mgAcetylcysteine Antidote Soln: 10, 20% Acetaminophen overdose: Initially 140 mg/kg, then 70 mg/kg q4h (Mucomyst) orally x 17 doses. All 17 doses must be given, even if acetaminophen levels have declined to non-toxic range.
Acitretin (Soriatane) Antipsoriatic Cap: 10, 25 mg 25-50 mg qd, full benefit in 2-3 months. Mandatory contraception, teratogenic, avoid alcohol and UV light exposure.
Acyclovir (Zovirax) Antiviral Tab: 400, 800 mg Cap: 200 mg Vial: 500, 1000 mg Susp: 200 mg/5 mL
Oint: 5% (3, 5 gm) Herpes Simplex: Initial infection: 200 mg five times a day or 400 mg tid for 10 days
or Recurrent infection: 400 mg tid or 800 mg bid for 5 days Severe infections or immunosuppressed: 5 mg/kg IV q8h for 5-7
days Suppressive therapy: 400 mg bid. Gastrointestinal upset.
Herpes varicella/zoster: Immunocompetent patients: 800 mg q4h (5 times a day) for 7 days Severely immunosuppressed or ophthalmic zoster: 10 mg/kg IV
over 1 hour q8h; keep patient well-hydrated; lethargy, confusion,
tremor. May cause meperidine toxicity. Encephalitis: 10 mg/kg IV over 1 hour, q8h x 14 days Adjust dose in renal failure, headache, rash. Apply to lesion 6 times daily x 7 daysAdapalene (Differin) Anti-acne Topical gel: 0.1% [15, 45 gm] Apply qhs after washing; photosensitizing; contraception mandatory;
teratogenic
Adenosine (Adeno-Antiarrhythmic Vial: 2 mL card) 6 mg IV push, then 12 mg x 2 doses; max 30 mg; theophylline and
methylxanthines antagonize its effect
Albumin (Albuminar) Plasma expander Soln: 25% [50, 100 mL] 5% [250, 500 mL] 50-100 mL of 25% soln IV, increases plasma oncotic pressure. 250-500 mL of 5% soln IV; contains 130-160 mEq sodium per literAlbuterol (Proventil, Bronchodilator Inhaler: [17 gm]
Ventolin, Volmax) Soln: 0.5% Repetabs: 4 mg Tab: 2, 4 mg 1-2 puffs bid-qid prn 0.5 mL in 2.5 mL NS q4-8h prn by nebulizer 4-8 mg sustained release tab bid 2-4 mg tid-qid; cardiac side effects, insomnia, anxiety.
